January 2024
New Lab Member: Ysabella Alcaraz joins the lab as a graduate student
November 2023
Article: bioRxiv, 2023 Nov
Title: "The pH-responsive SmrR-SmrT system modulatesC. difficileantimicrobial resistance, spore formation, and toxin production"
October 2023
Article: Infect Immun, 2023 Oct
Title: "Glycine fermentation by C. difficile promotes virulence and spore formation, and is induced by host cathelicidin"
October 2023
Article: PLoS Genet, 2023 October
Title: "The RgaS-RgaR two-component system promotes Clostridioides difficile sporulation through a small RNA and the Agr1 system"
July 2023
Article: bioRxiv, 2023 July
Title: "The predicted acetoin dehydrogenase pathway represses sporulation of Clostridioides difficile"
June 2023
Article: bioRxiv, 2023 June
Title: "The RgaS-RgaR two-component system promotes Clostridioides difficile sporulation through a small RNA and the Agr1 system"
March 2023
Article: bioRxiv, 2023 March
Title: "A Conserved Switch Controls Virulence, Sporulation, and Motility in C. difficile"
July 2022
Article: J Mol Biol, 2022 July
Title: "Identification of Functional Spo0A Residues Critical for Sporulation in Clostridioides difficile"
May 2022
Article J Bacteriol, 2022 May
TItle: "Three Orphan Histidine Kinases Inhibit Clostridioides difficile Sporulation"
April 2022
Article: Curr Opin Microbiol, 2022 April
Title: "Genetic mechanisms governing sporulation initiation in Clostridioides difficile"
December 2021
Article: mSphere, 2021 December
Title: "c-di-GMP Inhibits Early Sporulation in Clostridioides difficile"
September 2021
Conference Presentation: Germán G. Vargas-Cuebas Speaks at the 12th International Conference on the Molecular Biology and Pathogenesis of the Clostridia
August 2021
New Lab Member: Zavier Carter joined the McBride lab in August 2021 as a research specialist
August 2021
New Lab Member: Marcos Monteiro joins the lab as a graduate student
August 2021
New Lab Member: Christopher M. Kim joins the McBride Lab as an undergraduate student
June 2021
New Fellowship: Cheyenne Lee became an ARTDTP Fellow
May 2021
Article: ACS Infect Dis, 2021 May
Title: "Cationic Homopolymers Inhibit Spore and Vegetative Cell Growth of Clostridioides difficile"
May 2021
New lab member: Germán Vargas-Cuebas joins the lab as a graduate student in Microbiology and Molecular Genetics program.
April 2021
Article: Sci Rep, 2021 April
Title: "CD25890, a conserved protein that modulates sporulation initiation in Clostridioides difficile"
December 2020
New Award: Germán G. Vargas-Cuebas is awarded an F31 (NIDDK): Start date December 1st, 2020
August 2020
New Lab Member: Cheyenne Lee joins the lab in the Microbiology and Molecular Genetics program.
June 2020
New Fellowship: Germán G. Vargas-Cuebas becomes an ARTDTP Fellow
February 2020
Article: Appl Environ Microbiol, 2020 Feb
Title: "The Impact of pH on Clostridioides difficile Sporulation and Physiology"
January 2020
Article: J Bacteriol, 2020 Jan
Title: "Strain-Dependent RstA Regulation of Clostridioides difficile Toxin Production and Sporulation"
December 2019
Article: Antimicrob Agents Chemother, 2019 Dec
Title: "Regulation and Anaerobic Function of the Clostridioides difficile -Lactamase"
October 2019
Article: PLoS Biol, 2019 Oct
"Phase variation of a signal transduction system controls Clostridioides difficile colony morphology, motility, and virulence"
March 2019
Article: mBio, 2019 Mar
"RstA Is a Major Regulator of Clostridioides difficile Toxin Production and Motility"
December 2018
Article: Trends Microbiol, 2018 Dec
".Clostridioides difficile"
October 2018
Editorial: Anaerobe, 2018 Oct
July 2018
Article: PLoS Pathogens, 2018 Aug
Title: "The C. difficile clnRAB operon initiates adaptations to the host environment in response to LL-37"
June 2018
Article: Anaerobe, 2018 Jun
Title: "Examination of the Clostridioides (Clostridium) difficile VanZ ortholog, CD1240"
May 2018
New Lab Member: Germ an Vargas-Cuebas joined the lab as a Graduate Student.
April 2018
New Lab Member: Michael DiCandia joined the lab as a Graduate Student.
February 2018
New Lab Membert: Megan Woods rotated in the McBride Lab from February 2018 — March 2018.
January 2018
Article: Envron Microbiol, 2018 Jan
Title: "Ethanolamine is a Valuable Nutrient Source that Impacts Clostridium difficile Pathogenesis"
November 2017
New Lab Member: Brenda Antezana rotated in the McBride Lab from November 2017 — January 2018.
September 2017
New Lab Member: Michael DiCandia rotated in the McBride Lab from September 2017 — November 2017.
September 2017
New Lab Member: Grace Swaim rotated as an Undergraduate Research Assistant in the McBride Lab from September 2017 — February 2018.
June 2017
Article: Infect Immun, 2017 Jun
Title: "A nutrient-regulated cyclic diguanylate phosphodiesterase controls Clostridium difficile biofilm and toxin production during stationary phase"
May 2017
New Lab Member: Daniela Wetzel, PhD, joined the McBride Lab as a Postdoctoral Fellow.
April 2017
Article: Genome Announc, 2017 Apr
Title: "Genome sequence of a toxin-positive Clostridium difficile strain isolated from murine feces"
February 2017
New Lab Member: Monjori Mukerjee joined the McBride Lab as an Undergraduate Research Assistant, February 8, 2017 — May 1, 2018.
February 2017
Article: Bioprotocols, 2017 Feb
Title: "Determination of the in vitro Sporulation Frequency of Clostridium difficile"
November 2016
New Lab Member: Research Specialist Josh Jones joins the McBride Lab.
November 2016
Rotation student: Ogie Avramovska rotated in the McBride Lab November 21, 2016 — January 27, 2017.
October 2016
Article: Front Microbiol, 2016 Oct
Title: "Chemical and Stress Resistances of Clostridium difficile Spores and Vegetative Cells"
September 2016
Undergraduate Research Asst.: Kavita Athalye in McBride Lab, September 9, 2016 — January 17, 2017.
September 2016
Article: Virulence, 2016 Sept
Title: "What’s a SNP between friends: the influence of single nucleotide polymorphisms on virulence and phenotypes of Clostridium difficile strain 630 and derivatives"
August 2016
Article: Meth Mol Biol, 2016 Aug
Title: "Isolating and Purifying Clostridium difficile Spores"
May 2016
Article: J Bacteriol, 2016 May
Title: "CodY-dependent regulation of sporulation in Clostridium difficile"
May 2016
New Lab Member: Virginia Vachon, May 1, 2016 — August 31, 2016 .
April 2016
Article: Infect Immun, 2016 Apr
Title: "The Clostridium difficile Dlt pathway is controlled by the ECF sigma factor, σV, in response to lysozyme"
February 2016
Article: Emerg Microbe Infect, 2016 Feb
Title: "Immunogenicity and Protective Efficacy of Recombinant Clostridium difficile Flagellar protein FliC"
February 2016
Article: Mol Microbiol, 2016 Feb
Title: "A Novel Regulator Controls Clostridium difficile Sporulation, Motility and Toxin Production"
January 2016
New Rotation Student: Jessie Wozniak, January 4, 2016 — March 11, 2016.
December 2015
Article: Anaerobe, 2015 Dec
Title: "Immunogenicity and Protective Efficacy of Clostridium difficile Spore Proteins"
November 2015
New Undergraduate Research Assistant: Lina Jowhar, November 29, 2015 — April 13, 2020,
May 2015
Article: Antimicrob Agents Chemother, 2015 May
Title: "Effects of Surotomycin on Clostridium difficile Viability and Toxin Production in vitro"
May 2015
New Graduate Student: Sarah Anderson, May 1, 2015 — November 1, 2016.
January 2015
Article: Anaerobe, 2015 Jan
Title: "An Alkaline Phosphatase Reporter for use in Clostridium difficile"
January 2015
New Undergraduate Research Assistant: Samiha Karim, January 30, 2015 — April 13, 2020.
November 2014
Article: PLoS ONE, 2014 Nov
Title: "Functional Heterologous Protein Expression by Genetically Engineered Probiotic Yeast Saccharomyces boulardii"
October 2014
Article: Antibiotics, 2014 Oct
Title: "Mechanisms of Antimicrobial Peptide Resistance in Gram-positive Bacteria"
October 2014
Article: JACS, 2014 Oct
Title: "Synthetic Polymers Active Against Clostridium difficile Vegetative Cell Growth and Spore Outgrowth"
October 2014
New Rotation Student: Sarah Anderson, October 13, 2014 — December 18, 2014.
September 2014
New Lab Member: Christine Tien joined the lab from September 2, 2014 — May 31, 2017.
July 2014
Article: Infect Immun, 2014 Jul
Title: "Conserved Oligopeptide Permeases Modulate Sporulation Initiation in Clostridium difficile"
June 2014
Article: FEMS Micro Lett, 2014 Jun
Title: "Initiation of Sporulation in Clostridium difficile: a Twist on the Classic Model"
May 2014
New Lab member: Emily Woods joined the McBride lab from May 28, 2014 — May 1, 2018.
April 2014
Article: Microbe, 2014 Apr
Title: "More Than One Way to Make a Spore"
November 2013
New Lab Member: Kevin Childress joined the lab from November 12, 2013 — July 31, 2015.
September 2013
Article: J Vis Exp, 2013 Sept
Title: "Culturing and Maintaining Clostridium difficile in an Anaerobic Environment"
May 2013
New Lab Member: Silvia Dimitrova joined the McBride Lab from May 1, 2013 — October 28, 2013.
January 2013
New Lab Member: Katie Nawrocki, January 24, 2013 — November 15, 2016
January 2013
Article: J Bacteriol, 2013 Jan
Title: "Identification of CodY-targets in Bacillus anthracis by genome-wide in vitro binding analysis"
March 2013
Article: J Bacteriol, 2013 Mar
Title: "The Clostridium difficile cpr Locus is Regulated by a Non-contiguous Two-component System in Response to Type A and B Lantibiotics"
August 2012
New Lab Member: Adrianne Edwards joined the lab as Instructor.
July 2012
Article: J Bacteriol, 2012 July
Title: "Cyclic diguanylate inversely regulates motility and aggregation in Clostridium difficile"
January 2012
The McBride Lab’s Official Mascott: C. Diff the Seal
October 2011
New Lab Member: Jose Suarez joined the McBride Lab from October 1, 2011 — May 31, 2014.
May 2011
Article: Microbiol, 2011 May
Title: "The dlt Operon Confers Resistance to Cationic Antimicrobial Peptides in Clostridium difficile"
February 2011
Article: Curr Protoc Microbiol, 2011 Feb
TItle: "Genetic Manipulation of Clostridium difficile"
January 2011
Article: Infect Immun, 2011 Jan
Title: "Identification of a Genetic Locus Responsible for Antimicrobial Peptide Resistance in Clostridium difficile"
January 2011
Dr. McBride joins the Department of Microbiology and Immunology as an assistant professor. Her lab research focuses on identifying and understanding the genetic mechanisms used by the pathogen Clostridium difficile to subvert host defenses and survive within the mammalian intestine. Studies focus on two distinct aspects of C. difficile infections: the resistance of the bacterium to antimicrobial peptides and the formation of dormant spores in the host.