Welcome to our Lab
The mucosal surfaces of the respiratory, intestinal, and genital tracts are primary portals of entry for a wide range of pathogens. My laboratory studies the generation, maintenance, and recall of cellular immunity in the lung to better understand how pulmonary immune defenses can be harnessed to protect against respiratory pathogens.
The control of influenza and parainfluenza virus infections is mediated in part by T lymphocytes through the production of antiviral cytokines and the lysis of infected host cells within the lung tissue and lung airways. Following resolution of a primary infection, virus-specific memory T cells are established in secondary lymphoid organs and in peripheral tissues such as the lung tissue and lung airways. At the site of pathogen entry in the lung these cells can serve as sentinels to alert the immune system should a similar pathogen be reencountered, can help to orchestrate the appropriate secondary immune response, and can limit early pathogen replication.
Using a variety of molecular and genetic approaches to manipulate both the host and the pathogen, we are investigating how lung-resident lymphocytes are programmed to preferentially reside in the different compartments of the lung. We are also investigating the mechanisms these cells use to promote protective immunity, both directly through killing infected cells and indirectly through their interactions with other cells of the innate and adaptive immune system. Our goal is to translate these findings to develop vaccine strategies that promote the most efficacious immune memory for defense against respiratory pathogens. Finally, we are utilizing our knowledge of lung airway immunology during infection to address the dysregulation of immune function in the airways of patients with lung disease, with a particular focus on cystic fibrosis.
The control of influenza and parainfluenza virus infections is mediated in part by T lymphocytes through the production of antiviral cytokines and the lysis of infected host cells within the lung tissue and lung airways. Following resolution of a primary infection, virus-specific memory T cells are established in secondary lymphoid organs and in peripheral tissues such as the lung tissue and lung airways. At the site of pathogen entry in the lung these cells can serve as sentinels to alert the immune system should a similar pathogen be reencountered, can help to orchestrate the appropriate secondary immune response, and can limit early pathogen replication.
Using a variety of molecular and genetic approaches to manipulate both the host and the pathogen, we are investigating how lung-resident lymphocytes are programmed to preferentially reside in the different compartments of the lung. We are also investigating the mechanisms these cells use to promote protective immunity, both directly through killing infected cells and indirectly through their interactions with other cells of the innate and adaptive immune system. Our goal is to translate these findings to develop vaccine strategies that promote the most efficacious immune memory for defense against respiratory pathogens. Finally, we are utilizing our knowledge of lung airway immunology during infection to address the dysregulation of immune function in the airways of patients with lung disease, with a particular focus on cystic fibrosis.
Jacob Kohlmeier, PhD
Associate Professor
Microbiology and Immunology
