Investigating cell metabolism in myeloma and lung cancer
We investigate therapy resistance and the BCL-2 family of proteins in multiple myeloma and the metabolic basis of invasion/metastasis in lung adenocarcinoma.
We use metabolite profiling, metabolite flux and cellular bioenergetics assays and examine signaling in the context of biochemical, cellular and molecular interventions to investigate these questions in cell line, patient sample and in vivo models.
Our long-term goals are thus:
- To better understand the functional implications of altered cellular metabolism in cancer
- To elucidate how nutrient metabolism signals to promote cancer cell survival and metastasis
- To investigate cancer metabolism as a conduit to understanding therapy resistance that can be perturbed to orchestrate potent strategies of synthetic lethality with existing therapy