bioRxiv (pronounced "bio-archive") is a free online archive and distribution service for unpublished preprints in the life sciences. It is operated by Cold Spring Harbor Laboratory, a not-for-profit research and educational institution. By posting preprints on bioRxiv, authors are able to make their findings immediately available to the scientific community and receive feedback on draft manuscripts before they are submitted to journals.
2020
Measho H. Abreha, Shamsideen Ojelade, Eric B. Dammer, Zachary T. McEachin, Duc M. Duong, Marla Gearing, Gary J. Bassell, James J. Lah, Allan I. Levey, Joshua M. Shulman, Nicholas T. Seyfried. TBK1 interacts with tau and enhances neurodegeneration in tauopathy. bioRxiv 2020.06.17.157552
2019
Lenora Higginbotham, Lingyan Ping, Eric B. Dammer, Duc M. Duong, Maotian Zhou, Marla Gearing, Erik C.B. Johnson, Ihab Hajjar, James J. Lah, Allan I. Levey, Nicholas T. Seyfried. Integrated Proteomics Reveals Brain-Based Cerebrospinal Fluid Biomarkers in Asymptomatic and Symptomatic Alzheimer’s Disease. bioRxiv 806752.
Sruti Rayaprolu, Hailian Xiao, Supriya Ramesha, Duc Duong, Eric B Dammer, James J Lah, Allan I Levey, Nicholas T. Seyfried, Srikant Rangaraju. Quantitative multiplexed proteomics of mouse microglia by flow-cytometric sorting reveals a core set of highly-abundant microglial proteins. bioRxiv 802694.
Sean R. Kundinger, Isaac Bishof, Eric B. Dammer, Duc M. Duong, Nicholas T. Seyfried. Middle-down proteomics reveals dense sites of methylation and phosphorylation in arginine-rich RNA-binding proteins. bioRxiv 775122.
Michael J Chen, Supriya Ramesha, Laura D. Weinstock, Tianwen Gao, Lingyang Ping, Hailian Xiao, Eric B Dammer, Duc D Duong, Allan I Levey, James J Lah, Nicholas T. Seyfried, Levi B. Wood, Srikant Rangaraju. Microglial ERK signaling is a critical regulator of pro-inflammatory immune responses in Alzheimer’s disease. bioRxiv 798215.
Erik C.B. Johnson, Eric B. Dammer, Duc M. Duong, Lingyan Ping, Maotian Zhou, Luming Yin, Lenora A. Higginbotham, Andrew Guajardo, Bartholomew White, Juan C. Troncoso, Madhav Thambisetty, Thomas J. Montine, Edward B. Lee, John Q. Trojanowski, Thomas G. Beach, Eric M. Reiman, Vahram Haroutunian, Minghui Wang, Eric Schadt, Bin Zhang, Dennis W. Dickson, Nilufer Ertekin-Taner, Todd E. Golde, Vladislav A. Petyuk, Philip L. De Jager, David A. Bennett, Thomas S. Wingo, Srikant Rangaraju, Ihab Hajjar, Joshua M. Shulman, James J. Lah, Allan I. Levey, Nicholas T. Seyfried. A Consensus Proteomic Analysis of Alzheimer’s Disease Brain and Cerebrospinal Fluid Reveals Early Changes in Energy Metabolism Associated with Microglia and Astrocyte Activation. bioRxiv 802959.
Aliza P. Wingo, Wen Fan, Duc M. Duong, Ekaterina S. Gerasimov, Eric B. Dammer, Bartholomew White, Madhav Thambisetty, Juan C. Troncoso, Julie A. Schneider, James J. Lah, David A. Bennett, Nicholas T. Seyfried, Allan I. Levey, Thomas S. Wingo. Cerebral atherosclerosis contributes to Alzheimer’s dementia independently of its hallmark amyloid and tau pathologies. bioRxiv 793349.
Thomas S. Wingo, Jingjing Yang, Wen Fan, Benjamin Logsdon, Se Min Canon, Bing Yao, Nicholas T. Seyfried, James J. Lah, Allan I Levey, Patricia A. Boyle, Julia A. Schneider, Philip L. De Jager, David A. Bennett, Aliza P. Wingo. Brain microRNAs associated with late-life depressive symptoms are also associated with cognitive trajectory and dementia. bioRxiv 620815.
Yi-Chen Hsieh, Caiwei Guo, Hari K. Yalamanchili, Measho Abreha, Rami Al-Ouran, Yarong Li, Eric B. Dammer, James J. Lah, Allan I. Levey, David A. Bennett, Philip L. De Jager, Nicholas T. Seyfried, Zhandong Liu, Joshua M. Shulman. Tau-mediated Disruption of the Spliceosome Triggers Cryptic RNA-splicing and Neurodegeneration in Alzheimer’s Disease. bioRxiv 514927.
Aliza P Wingo, Eric B Dammer, Michael S Breen, Benjamin A Logsdon, Duc M Duong, Juan C. Troncosco, Madhav Thambisetty, Thomas G Beach, Geidy E Serrano, Eric M Reiman, Richard J Caselli, James J Lah, Nicholas T. Seyfried, Allan I Levey, Thomas S Wingo. Large-scale proteomic analysis of human prefrontal cortex identifies proteins associated with cognitive trajectory in advanced age. bioRxiv 526988.
2018
Paul R. Evans, Kyle J. Gerber, Eric B. Dammer, Duc M. Duong, Devrishi Goswami, Daniel J. Lustberg, Juan Zou, Jenny J. Yang, Serena M. Dudek, Patrick R. Griffin, Nicholas T. Seyfried, John R. Hepler Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calmodulin (CaM) Effector in Mouse Brain. bioRxiv 247270.
Noam D. Beckmann, Wei-Jye Lin, Minghui Wang, Ariella T. Cohain, Pei Wang, Weiping Ma, Ying-Chih Wang, Cheng Jiang, Mickael Audrain, Phillip Comella, Siddharth P. Hariharan, Gillian M. Belbin, Allan I. Levey, Nicholas T. Seyfried, Eric B. Dammer, Duc Duong, James J. Lah, Jean-Vianney Haure-Mirande, Ben Shackleton, Alexander W. Charney, Eimear Kenny, Jun Zhu, Vahram Haroutunian, Pavel Katsel, Sam Gandy, Zhidong Tu, Michelle Ehrlich, Bin Zhang, Stephen R. Salton, Eric E. Schadt. Multiscale causal network models of Alzheimer’s disease identify VGF as a key regulator of disease. bioRxiv 458430.
Avanti Gokhale, Amanda A. H. Freeman, Cortnie Hartwig, Julia L. Bassell, Stephanie A. Zlatic, Christie Sapp, Trishna Vadlamudi, Farida Abudulai, Amanda Crocker, Erica Werner, Zhexing Wen, Gabriela M. Repetto, Joseph A. Gogos, Steven M. Claypool, Jennifer K. Forsyth, Carrie Bearden, Jill Gausier, David A. Lewis, Nicholas T. Seyfried, Victor Faundez. Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior. bioRxiv 315143.
Isaac Bishof, Eric B. Dammer, Duc M. Duong, Marla Gearing, James J. Lah, Allan I. Levey, Nicholas T. Seyfried. RNA-binding proteins with mixed charge domains self-assemble and aggregate in Alzheimer’s Disease. bioRxiv 243014.