Publications

An intra-tumoral niche maintains and differentiates stem-like CD8 T cells 
CS Jansen, N Prokhnevska, VA Master, MG Sanda, JW Carlisle, MA Bilen, ... 
Nature 576 (7787), 465-470 
 
Androgens alter T-cell immunity by inhibiting T-helper 1 differentiation 
HT Kissick, MG Sanda, LK Dunn, KL Pellegrini, ST On, JK Noel, ... 
Proceedings of the National Academy of Sciences 111 (27), 9887-9892 
 
CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor 
N Prokhnevska, MA Cardenas, RM Valanparambil, E Sobierajska, ... 
Immunity 56 (1), 107-124. e5  
 
The role of active vaccination in cancer immunotherapy: lessons from clinical trials 
HT Kissick, MG Sanda 
Current opinion in immunology 35, 15-22 
 
Clinical outcome following checkpoint therapy in renal cell carcinoma is associated with a burst of activated CD8 T cells in blood 
JW Carlisle, CS Jansen, MA Cardenas, E Sobierajska, AM Reyes, ... 
Journal for Immunotherapy of Cancer 10 (7), e004803 
 
CMV status drives distinct trajectories of CD4+ T cell differentiation 
W Zhang, AB Morris, EV Peek, G Karadkhele, JM Robertson, HT Kissick, ... 
Frontiers in Immunology 12, 620386 
 
The requirement for immune infiltration and organization in the tumor microenvironment for successful immunotherapy in prostate cancer 
CS Jansen, N Prokhnevska, HT Kissick 
Urologic Oncology: Seminars and Original Investigations 37 (8), 543-555 
 
Development of a peptide-based vaccine targeting TMPRSS2: ERG fusion-positive prostate cancer 
HT Kissick, MG Sanda, LK Dunn, MS Arredouani 
Cancer Immunology, Immunotherapy 62, 1831-1840 
 
Immunization with a peptide containing MHC class I and II epitopes derived from the tumor antigen SIM2 induces an effective CD4 and CD8 T-cell response 
HT Kissick, MG Sanda, LK Dunn, MS Arredouani 
PLoS One 9 (4), e93231 
 
Immunological complexity of the prostate cancer microenvironment influences the response to immunotherapy 
N Prokhnevska, DA Emerson, HT Kissick, WL Redmond 
Prostate Cancer: Cellular and Genetic Mechanisms of Disease Development and … 
 
The transcription factor ERG increases expression of neurotransmitter receptors on prostate cancer cells 
HT Kissick, ST On, LK Dunn, MG Sanda, JM Asara, KL Pellegrini, JK Noel, ... 
BMC cancer 15, 1-9 
 
Is it possible to develop cancer vaccines to neoantigens, what are the major challenges, and how can these be overcome? Neoantigens as vaccine targets for cancer 
HT Kissick 
Cold Spring Harbor Perspectives in Biology 10 (11), a033704 
 
Organized immune cell interactions within tumors sustain a productive T-cell response 
MA Cardenas, N Prokhnevska, HT Kissick 
International Immunology 33 (1), 27-37 
 
New epigenetic regulators of T cell exhaustion 
H Kissick, R Ahmed 
Cancer Cell 40 (7), 708-710 
 
An early precursor CD8 T cell that adapts to acute or chronic viral infection 
DT McManus, RM Valanparambil, CB Medina, CD Scharer, DJ McGuire, ... 
Nature, 1-3 
 
Differentiation fate of a stem-like CD4 T cell controls immunity to cancer 
MA Cardenas, N Prokhnevska, E Sobierajska, P Gregorova, CB Medina, ... 
Nature 636 (8041), 224-232 
 
Immune niches in brain metastases contain TCF1+ stem-like T cells, are associated with disease control and are modulated by preoperative SRS 
CS Jansen, RS Prabhu, MS Pagadala, P Chappa, S Goyal, C Zhou, ... 
Research Square, rs. 3. rs-2722744 
 
Enfortumab vedotin plus pembrolizumab in the treatment of locally advanced or metastatic bladder cancer of variant histology: A phase II study. 
B Nazha, JT Brown, Y Liu, H Kissick, BC Carthon, O Kucuk, LR Harik, ... 
Journal of Clinical Oncology 42 (16_suppl), TPS4615-TPS4615 
 
Major histocompatibility complex and peptide specificity underpin CD8+ T cell direct alloresponse 
W Zhang, FM Roversi, AB Morris, K Ortiz, G Zhou, A Hadley, X Zhang, ... 
American Journal of Transplantation 
 
Pre-operative stereotactic radiosurgery and peri-operative dexamethasone for resectable brain metastases: a two-arm pilot study evaluating clinical outcomes and immunological … 
CS Jansen, MS Pagadala, MA Cardenas, RS Prabhu, S Goyal, C Zhou, ... 
Nature Communications 15 (1), 8854 
 
Tumor-specific CD8 T cell activation in draining lymph nodes supports the anti-tumor CD8 T cell response 
N Prokhnevska, M Cardenas, C Jansen, R Valanparambil, V Master, ... 
The Journal of Immunology 204 (1_Supplement), 165.5-165.5 
 
Identification of indirect CD4+ T cell epitopes associated with transplant rejection provides a target for donor-specific tolerance induction 
Z Zhanzak, AC Johnson, P Foster, MA Cardenas, AB Morris, J Zhang, ... 
Immunity 
 
Neoadjuvant cabozantinib restores CD8+ T cells in patients with locally advanced non-metastatic clear cell renal cell carcinoma: A phase 2 trial 
MA Bilen, BHT Vo, Y Liu, R Greenwald, AH Davarpanah, D McGuire, ... 
Research Square, rs. 3. rs-4849400 
 
Stem-like CD4 T differentiation controls CD8 T cell immunity or tolerance in cancer 
MA Cardenas, N Prokhnevska, CS Jansen, E Sobierajska, V Master, ... 
The Journal of Immunology 210 (Supplement_1), 86.04-86.04