Biochemistry
| Principal Investigator | Award | Sponsor Name | Proposal Type | Award Period |
| Conn, Graeme Leslie | New insight into innate immune regulation through mechanistic studies of a novel oligoadenylate synthetase-like (OASL) gain-of-function variant | NIH NATL INST OF ALLERGY AND INFECTIOUS | Continuation | 01-JUN-24 - 30-APR-26 |
| Conn, Graeme Leslie | Mechanisms and biological functions of SPOUT methyltransfereases | OHIO STATE UNIVERSITY | New | 01-SEP-23 - 31-JUL-27 |
| Kahn, Richard A | Molecular mechanisms of ARF family GTPases | NIH NATL INSTITUTE OF GENERAL MEDICAL SC | Continuation | 01-SEP-22 - 31-AUG-27 |
| Liang, Bo | Structure and Regulation of The Respiratory Syncytial Virus Polymerase | NIH NATL INSTITUTE OF GENERAL MEDICAL SC | Supplemental | 25-SEP-24 - 31-JUL-28 |
| Liang, Bo | Metabolic control of human endothelial development via the COUP-TF/1-deoxysphingos | UNIV OF GEORGIA | New | 01-MAR-24 - 29-FEB-28 |
| Liang, Bo | Functions and structures of the Nipah virus polymerase | UNIVERSITY OF TEXAS MEDICAL BRANCH | Continuation | 01-MAY-23 - 30-APR-25 |
| Liang, Bo | Production of Highly Purified Proteins and Structure Determination of Antigen-ant | CENTERS FOR DISEASE CONTROL | New | 12-SEP-24 - 11-SEP-25 |
| Ortlund, Eric A. | Them1 Inhibitors for the Management of Non-Alcoholic Fatty Liver Disease | BRIGHAM AND WOMENS HOSPITAL | New | 01-JUL-23 - 30-APR-28 |
| Ortlund, Eric A. | Targeting the orphan nuclear receptor LRH-1 with small molecules | NIH NATL INST OF DIABETES DIGESTIVE AND | New | 01-SEP-23 - 31-JUL-27 |
| Ortlund, Eric A. | THEM1-Mediated Metabolic Regulation and Pathogenic Role in NAFLD | BRIGHAM AND WOMENS HOSPITAL | Continuation | 01-JUL-23 - 30-JUN-24 |
| Ortlund, Eric A. | Targeting LRH-1 for Ulcerative Colitis | GEORGIA RESEARCH ALLIANCE | New | 31-AUG-23 - 31-MAR-24 |
| Seyfried, Nicholas T. | Risk Factors, Pathology, and Clinical Expressions of AD | RUSH UNIVERSITY MEDICAL CENTER | Continuation | 15-JUL-19 - 30-APR-24 |
| Seyfried, Nicholas T. | Generation, Characterization, and Validation of Marmoset Models of Alzheimer's Disease | UNIVERSITY OF PITTSBURGH | Continuation | 01-SEP-22 - 31-AUG-27 |
| Seyfried, Nicholas T. | The IU/JAX Alzheimer's Disease Precision Models Center | INDIANA UNIVERSITY | Continuation | 30-SEP-22 - 31-AUG-27 |
| Seyfried, Nicholas T. | Investigating the role of TMEM106b genetics and pathology in Alzheimer's disease | MAYO CLINIC | New | 22-SEP-23 - 31-AUG-28 |
| Sundberg, Eric J. | Gatekeeping glycan metabolism in the human gut microbiome | NIH NATL INSTITUTE OF GENERAL MEDICAL SC | Supplemental | 08-APR-20 - 31-MAR-25 |
Cell Biology
Post-transcriptional mechanisms of centrosome regulation
| Principal Investigator | Award | Sponsor Name | Proposal Type | Award Period |
| Banks, Emily | Interneuron dysfunction and the emergence of tau pathology in early Alzheimer’s disease | NIH NATL INSTITUTE ON AGING | Continuation | 06-DEC-23 - 05-DEC-27 |
| Bekele, Bethlehem Alemayehu | Altered Inhibitory Neurotransmission in Mouse Models of Myotonic Dystrophy | Myotonic Dystrophy Foundation | New | 01-JAN-24 - 31-DEC-25 |
| Das, Sulagna | Mechanism of mRNA Localization and Localized Translation in Neurons | Albert Einstien College of Medicine | Continuation | 01-JAN-24 - 31-AUG-27 |
| Emanuel, Alan J | Contextual Representation of Tactile Information in Mouse Primary Somatosensory Cortex | NIH NATL INST OF NEUROLOGICAL DISORDERS | Continuation | 01-JAN-23 - 31-DEC-25 |
| Goldy, Jordan Nelson | An Evolutionarily Conserved RNA Binding Protein Critical for Proper Neuronal Function Regulates Lipid Storage and Metabolic Pathways | NIH NATL INST OF NEUROLOGICAL DISORDERS | New | 01-SEP-24 - 31-AUG-27 |
| Lerit, Dorothy Anne | Post-transcriptional mechanisms of centrosome regulation | NIH NATL INST OF GENERAL MEDICAL SCIENCE | Continuation | 01-AUG-20 - 30-JUN-25 |
| Lerit, Dorothy Anne | Post-transcriptional mechanisms of centrosome regulation | NIH NATL INST OF GENERAL MEDICAL SCIENCE | Supplemental | 01-AUG-20 - 30-JUN-25 |
| Moberg, Kenneth Harold | Control of Drosophila intestinal homeostasis by RhoGap15b | NIH NATL INSTITUTE ON AGING | New | 15-SEP-24 - 31-AUG-25 |
| Pottorf, Tana Sue | Microglial Activity on Injured Motoneurons | NIH NATL INST OF NEUROLOGICAL DISORDERS | Continuation | 01-SEP-23 - 31-AUG-26 |
| Sampson, Timothy Robert | Interaction of Pyrethroid Exposure and the Microbiome on Parkinson's Disease related Pathologies | NIH NATL INST OF ENVIRONMENTAL HLTH SCIE | Continuation | 09-FEB-22 - 30-NOV-26 |
| Sampson, Timothy Robert | Interaction of Pyrethroid Exposure and the Microbiome on Parkinson's Disease related Pathologies | NIH NATL INST OF ENVIRONMENTAL HLTH SCIE | Supplemental | 09-FEB-22 - 30-NOV-26 |
| Ward, Patricia Jill | Tacrolimus eluting nanofiber constructs for nerve repair | Axocell | New | 28-OCT-24 - 27-OCT-25 |
| Ward, Patricia Jill | Axonal G3BP1 aggregation as an | UNIVERSITY OF SOUTH CAROLINA | Continuation | 01-JUL-20 - 30-JUN-25 |
| Ward, Patricia Jill | Sympathetic Function in Neural Injuries | NIH NATL INST OF NEUROLOGICAL DISORDERS | Renewal | 01-DEC-24 - 30-NOV-26 |
| Zhang, Shirley | Circadian rhythm regulation of blood-brain barrier transport and inflammation | NIH NATL INST OF NEUROLOGICAL DISORDERS | Continuation | 06-DEC-23 - 30-NOV-25 |
| Zheng, James Q | Actin Cytoskeleton in Postsynaptic Structure and Function | NIH NATL INSTITUTE OF MENTAL HEALTH | Continuation | 03-JUN-24 - 31-DEC-27 |
Microbiology and Immunology
CASE WESTERN RESERVE UNIVERSITY
| Principal Investigator | Award | Sponsor Name | Proposal Type | Award Period |
| Ahmed, Rafi | Vaccine Induced Immunity in the Young and Aged | NIH NATL INST OF ALLERGY AND INFECTIOUS | Renewal | 28-AUG-24 - 31-JUL-29 |
| Ahmed, Rafi | Mt. Sinai - Emory Multi-institutional CIVIC | MOUNT SINAI SCHOOL OF MEDICINE | Continuation | 10-SEP-19 - 24-SEP-25 |
| Ahmed, Rafi | T Cell Memory to Viruses | NIH NATL INST OF ALLERGY AND INFECTIOUS | New | 12-JUN-24 - 30-APR-29 |
| Ahmed, Rafi | Exploiting the mechanobiology of PD-1 for cancer immunotherapy | GEORGIA INSTITUTE OF TECHNOLOGY | Continuation | 01-JUN-20 - 31-MAY-25 |
| Ahmed, Rafi | Immunological Landscapes in Persistent HPV Infection in India | BILL AND MELINDA GATES FOUNDATION | New | 25-OCT-24 - 30-NOV-26 |
| Basu Thakur, Poulami | CDC IPA: POULAMI BASU THAKUR | GEORGIA INSTITUTE OF TECHNOLOGY | Continuation | 30-JUN-24 - 29-JUN-25 |
| Boss, Jeremy M | Epigenetic regulation of early B cell differentiation | NIH NATL INST OF ALLERGY AND INFECTIOUS | New | 01-JUL-24 - 31-MAY-29 |
| Boss, Jeremy M | Hydrogel-based Aged immune Organoids to Study Epiegentics and Trajectory of B cell | GEORGIA INSTITUTE OF TECHNOLOGY | New | 01-JUL-24 - 31-MAY-29 |
| Lakdawala, Seema | Flu Lab - Human Challenge Phase I | NATIONAL PHILANTHROPIC TRUST | Continuation | 01-MAR-23 - 28-FEB-27 |
| LaRock, Christopher N | Proteolytic regulation of the Streptococcus pyogenes cell surface | NIH NATL INST OF ALLERGY AND INFECTIOUS | Continuation | 15-JAN-21 - 31-DEC-25 |
| LaRock, Christopher N | GSDMA roles in skin innate immune defense | NIH NATL INST OF ALLERGY AND INFECTIOUS | Continuation | 17-JUN-24 - 30-APR-29 |
| Lowen, Anice C. | Development of Oncolytic Reovirus for Triple-Negative Breast Cancer | NIH NATL INST OF ALLERGY AND INFECTIOUS | Continuation | 10-JAN-20 - 31-DEC-25 |
| Lowen, Anice C. | Impact of intra-host population structure on influenza virus antigenic evolution | NIH NATL INST OF ALLERGY AND INFECTIOUS | Continuation | 09-DEC-21 - 30-NOV-26 |
| Lowen, Anice C. | CEIRR: SARS-CoV-2 Research Activities | NIH NATL INST OF ALLERGY AND INFECTIOUS | Continuation | 01-APR-21 - 17-SEP-26 |
| Mattingly, Cameron LaRue Robinson | Duration and Function of Lung Tissue Resident CD8+ Memory T cells | NIH NATL HEART LUNG AND BLOOD INSTITUE | Continuation | 01-FEB-23 - 31-JAN-25 |
| Medina, Christopher | Defining the unique classes of inhibitory receptor molecules during CD8+ T cell | HOWARD HUGHES MEDICAL INSTITUTE | Continuation | 01-OCT-22 - 30-SEP-25 |
| Neufeldt, Christopher | Host factor contribution to positive-strand RNA virus induced membrane reorganization | NIH NATL INST OF ALLERGY AND INFECTIOUS | Continuation | 11-JUN-24 - 30-APR-29 |
| Rather, Philip | Understanding B-lactam resistance in Acinetobacter baumannii | CASE WESTERN RESERVE UNIVERSITY | Renewal | 15-MAY-24 - 31-MAR-29 |
Pharmacology and Chemical Biology
| Principal Investigator | Award | Sponsor Name | Proposal Type | Award Period |
| Feng, Yue | Regulation and function of human neural circular RNAs | NIH NATL INST OF NEUROLOGICAL DISORDERS | Continuation | 15-MAR-21 - 31-DEC-25 |
| Ganesh, Thota | Development of EP2 Receptor Antagonist to Treat Alzheimer's Disease | NIH NATL INSTITUTE ON AGING | New | 20-SEP-24 - 30-JUN-29 |
| Golde, Todd E. | A consortium effort to translate therapies for neurological diseases | UNIVERSITY OF NORTH CAROLINA CHAPEL HILL | Continuation | 01-AUG-22 - 30-APR-25 |
| Golde, Todd E. | Searching for the Goldilocks Zone of Innate Immunity in Alzheimer's Disease | NIH NATL INSTITUTE ON AGING | New | 26-SEP-24 - 30-JUN-29 |
| Levites, Yona | Amyloidosis associated proteins in Alzheimer's disease pathogenesis | UNIVERSITY OF FLORIDA | New | 01-SEP-24 - 31-AUG-26 |
| Mo, Xiulei | Discovery of small molecule mutant SMAD4-PPI inducers | NIH NATL CANCER INSTITUTE | Supplemental | 01-AUG-21 - 31-JUL-25 |
| Traynelis, Stephen F | Evaluation of Radiprodil on GRIN GOF Variants In Vitro | GRIN THERAPEUTICS | Continuation | 01-JAN-24 - 31-MAR-25 |
| Varvel, Nicholas H | Brain-invading monocytes promote the deleterious consequences of status epilepticus | NIH NATL INST OF NEUROLOGICAL DISORDERS | Continuation | 01-DEC-19 - 30-NOV-25 |