Our Projects

Enterobacterales are increasingly resistant to multiple antibiotics, making them a global epidemic public health threat. Multi-drug resistant Enterobacterales (MDR Ent) infections were historically limited to healthcare settings, but over the past two decades there have been significant increases in infections occurring in otherwise healthy children and adults without prior healthcare contact.

Enterobacterales are increasingly resistant to multiple antibiotics, making them a global epidemic public health threat. Extended-spectrum beta-lactamase-producing Enterobacterales (ESBL Ent) infections were historically limited to healthcare settings, but over the past two decades there have been significant increases in infections occurring in otherwise healthy children and adults without prior healthcare contact.

Multi-drug resistant (MDR) and more specifically, extended-spectrum beta-lactamase-producing Enterobacterales (ESBL Ent) have emerged as a serious public health threat. The incidence of ESBL Ent infections has increased dramatically during the past decade, now reaching nearly 200,000 infections and over 9,000 deaths per year in the US.

Sewage contains antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs), some of which may persist, be amplified, or attenuated through wastewater treatment. To support comprehensive strategies to mitigate the spread of antimicrobial resistance (AMR), there is a need to better quantify outputs of ARB/ARGs from wastewater treatment plants (WWTPs) to the environment and to characterize potential impacts.