APPLES-TELE
Supporting Parents to Help Babies and Toddlers Develop Arm and Hand Function
APPLES-TELE is a clinical trial designed to look at a parent-based motor and education intervention in young children with asymmetric quadriplegic or hemiplegic cerebral palsy (CP). The interventions are designed to help children move and use their arms like other children at an early age. Implementing a parent-centered approach increases participation and using telemedicine can improve accessibility to the medical team.
MANZANAS: APPLES-TELE
MANZANAS is a culturally tailored version of APPLES-TELE, designed for Spanish-speaking families. For more information on MANZANAS, please contact BBOPLabEmorySpanish@gmail.com.
Who Can Participate in the Study?
Children may be able to participate if they are 4-13 months corrected age, have CP or have been told they are at high risk for CP, and show a difference in the way they use one arm or hand compared to the other.
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HINE Validation
Hammersmith Infant Neurological Exam (HINE) Telehealth Validation Study for CORD-CHD
The HINE Validation study was created to test the reliability of scores on telehealth HINE assessment compared to in-person HINE assesments. The ability to administer the HINE virtually can help increase early access to neurodevelopmental screening.
Who Can Participate in the Study?
Children may be able to participate if they are 22-26 months chronological age, were born at term (over 37 weeks), and can come in-person to our Atlanta-based lab for the study.
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GMAT
General Movements Assessments in the NICU
Early detection and referral to evidence-based interventions can improve long-term outcomes of infants with neurological and motor disorders. The General Movements Assessment (GMA) is one of the most highly predictive screening tools for the detection of neuro-motor disorders. The GMA is a visual evaluation using video recordings analyzed by trained examiners of an infants movements that identify abnormal patterns (produced by central generators in the brain) with high sensitivity and specificity for neuro-motor problems. However, access to this screening exam is limited due to high costs and lack of readily available training. This study works to develop the pressure sensor system and software to quickly and accurately identify children at risk for neuro-motor disorders.
Who Can Participate in the Study?
Babies at certain hospitals in the United States between 36-44 weeks corrected age (with some exclusions).
smallTalk
Development of a Therapeutic Device to Improve Speech Sound Differentiation in Preterm Infants
smallTalk is a clinical trial designed to evaluate the effectiveness of an intervention using mom’s voice in the NICU in improving pre-term infants’ ability to tell the difference between different speech sounds. This early speech sound differentiation skill is essential to later language development.
Who Can Participate in the Study?
Babies who are born <35 weeks gestational age (with some exclusions) and who are receiving care at participating hospitals in Atlanta.
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Development of a Therapeutic Device to Improve Speech Sound Differentiation in Preterm Infants
COOLPRIME
Comparative Effectiveness for Cooling Prospectively Infants with Mild Encephalopathy
COOLPRIME is a study taking place at multiple hospitals around the country and Ireland. This study compares outcomes for babies with mild HIE who received cooling or non-cooling protocols. Researchers hope to learn about the effects of body cooling for mild HIE on babies and family outcomes.
Who Can Participate in the Study?
Babies who meet the definition of mild HIE and are receiving care at participating hospitals in the United States.