Publications

2025

D. Hass, E. Giering, J. Han, C. Bisbach, K. Pandey, B. Robbings, T. Mundinger, N. Nolan, S. Tsang, N. Peachey, N. Philp, J. Hurley. In vivo exchange of glucose and lactate between photoreceptors and the retinal pigment epithelium. bioRxiv, 12/2024 (https://www.biorxiv.org/content/10.1101/2023.04.10.536306v2)

S. Caruso, X. Cui, B. Robbings, N. Heaps, A. Demikrol, B. Costa, D. Hass, P. Quinn, J. Du, J. Hurley, S. Tsang.  Cell-specific reprogramming of HIFs rescues preclinical model of retinitis pigmentosa and illuminates RPE/photoreceptor metabolic coupling. (Accepted, JCI)

2024

D. Hass, K. Pandey, A. Engel, N. Horton, B. Robbings, M. Sadilek, R. Lim, Q. Zhang, G. Autterson, J. Miller, J. Chao, J. Hurley. Acetyl-CoA carboxylase inhibition increases RPE cell fatty acid oxidation and limits apolipoprotein efflux. J. Biol Chem., 11/2023, (https://www.jbc.org/article/S0021-9258(24)02273-7/fulltext)

G. Gulette, D. Hass, K. Pandey, Q. Zhang, J.S. Han, A. Engel, J. Chao, N. Philp, J. Hurley, J. Miller. Reassessing Retinal Pigment Epithelial Ketogenesis: Enzymatic Assays for Ketone Body Levels Provide Inaccurate Results. Exp Eye Res. 06/2024 (https://doi.org/10.1016/j.exer.2024.109966)

N. Nolan, X. Cui, B. Robbings, A. Demirkol, K. Pandey, W. Wu, H. Hu, L. Jenny, C. Lin, D. Hass, J. Du, J. Hurley, S. Tsang. CRISPR editing of anti-anemia drug target rescues independent preclinical models of retinitis pigmentosa. Cell Rep Med. 04/2024 (https://doi.org/10.1016/j.xcrm.2024.101459)

2023

V. Kamat, M. Grumbine, K. Bao, K. Mokate, G. Khalil, D. Cook, B. Clearwater, R. Hirst, J. Harmon, M. Boeck, Z. Fu, L. Smith, M. Goswami, T. Wubben, E. Walker, J. Zhu, S. Soleimanpour, J. Scarlett, B. Robbings, D. Hass, J. Hurley, I. Sweet. A Versatile Pumpless Multi-Channel Fluidics System for the Maintenance and Real-Time Metabolic and Functional Assessment of Tissue or Cells. (https://www.sciencedirect.com/science/article/pii/S2667237523003132?via%3Di hub)

D. Hass*, Q. Zhang*, G. Autterson, R. Bryan, J. Hurley, J. Miller. Medium depth influences O2 availability and metabolism in cultured RPE cells. IOVS, 11/2023 (https://doi.org/10.1167/iovs.64.14.4)    *Co-first authors

M. Grumbine, V. Kamat, K. Bao, K. Mokate, R. Lim, J. Chao, B. Robbings, D. Hass, J. Hurley, I. Sweet. Procedures for Maintaining and Assessing Various Tissue- and Cell-Types of the Eye with the BaroFuse. J Vis Exp, 7/2023 (https://www.jove.com/t/65399/maintaining-assessing-various-tissue-cell-types- eye-using-novel)

2022

B. Berkowitz, R. Podolsky, K. Childers, R. Roberts, R. Katz, R. Wasee, B. Robbings, D. Hass, J. Hurley, I. Sweet, C. Goodman, H. Qian, B. Alvisio, S. Heaps. Transducin-Deficient Rod Photoreceptors Evaluated With Optical Coherence Tomography and Oxygen Consumption Rate Energy Biomarkers. IOVS, 2022. (https://iovs.arvojournals.org/article.aspx?articleid=2785229&resultClick=1)

D. Hass, C. Bisbach, B. Robbings, M. Sadilek, I. Sweet, and J. Hurley. Succinate Uncouples Retinal Pigment Epithelium Mitochondria. Cell Rep., 2022. (https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00694-5)

C. Bisbach, D. Hass, E. Thomas, T. Cherry, and J. Hurley. Monocarboxylate Transporter 1 (MCT1) mediates succinate export in the retina. IOVS, 2022. (https://iovs.arvojournals.org/article.aspx?articleid=2778719)

2021

K. Tsantilas, W. Cleghorn, C. Bisbach, J. Whitson, D. Hass, B. Robbings, M. Sadilek, J. Linton, A. Rountree, A. Valencia, M. Sweetwyne, M. Campbell, H. Zhang, C. Jankowski, I. Sweet, D. Marcinek, P. Rabinovitch, and J. Hurley. An analysis of metabolic changes in the retina and retinal pigment epithelium of aging mice. IOVS, 2021. (https://iovs.arvojournals.org/article.aspx?articleid=2778095&resultClick=1)

2020

C. Bisbach, D. Hass, B. Robbings, A. Roundtree, M. Sadiliek, I. Sweet, J. Hurley Succinate Can Shuttle Reducing Power from the Hypoxic Retina to the O2-Rich Pigment Epithelium. Cell Rep. 2020. (https://www.cell.com/cell-reports/pdf/S2211-1247(20)30555-6.pdf)

2019

D. Hass, C. Barnstable. Mitochondrial Uncoupling Protein 2 Knockout Promotes Mitophagy to Decrease Retinal Ganglion Cell Death in Glaucoma. J Neurosci. 2019. (http://www.jneurosci.org/content/early/2019/02/27/JNEUROSCI.2702- 18.2019)

D. Hass, C. Barnstable. Cell Autonomous Neuroprotection by the Mitochondrial Uncoupling Protein 2 in a Mouse Model of Glaucoma. Front Neurosci. 2019. (https://www.frontiersin.org/articles/10.3389/fnins.2019.00201/abstract)

2018

T. Xing*, D. Hass*, S. Zhang, C. Barnstable. The PDK-1-p70S6K Axis Negatively Regulates Rod Photoreceptor Differentiation. Front Cell Dev Bio. 2018. (https://www.frontiersin.org/articles/10.3389/fcell.2018.00134/full)

D. Hass, K. Pandey, B. Robbings, R. Lim, J. Chao, J. Hurley. Less is more: the RPE cell culture medium additive mildly impairs cell health. (Accepted, Experimental Medicine and Biology)

D. Hass, C. Bisbach, M. Sadilek, I. Sweet, and J. Hurley. Aerobic glycolysis in photoreceptors supports energy demand in the absence of mitochondrial coupling. Advances in Experimental Medicine and Biology. 07/2023 (https://link.springer.com/chapter/10.1007/978-3-031-27681-1_64)

D. Hass and C. Barnstable. Uncoupling proteins in the mitochondrial defense against oxidative stress. Prog. Ret. Eye Res. 2021 (https://www.sciencedirect.com/science/article/abs/pii/S1350946221000021)

D. Hass, C. Barnstable. Uncoupling Protein 2 in the Glial Response to Stress: Implications for Neuroprotection. Neural Regen. Res. 2016. (http://www.nrronline.org/article.asp?issn=1673- 5374;year=2016;volume=11;issue=8;spage=1197;epage=1200;aulast=Hass;type =0)