The LaRock Lab is part of the Department of Microbiology and Immunology
Chou S, Sun J, LaRock D, LaRock C. Therapeutic inhibition of metalloproteases by tetracyclines during multi-drug resistance Pseudomonas aeruginosa infection. BioRxiv(2025)
Johnson A, Bushman S, LaRock D, Manuel Díaz J, McCormick J, LaRock C. Proinflammatory synergy between protease and superantigen streptococcal pyogenic exotoxins. Infection and Immunity (2025)
Salar Amoli M, Jin L, Rezapourdamanab S, Saadeh M, Singh Y, Ning L, Hwang B, Tomov M, LaRock C, Mahmoudi M, Bauser-Heaton H, Serpooshan V. Protocol for 3D bioprinting of nanoparticle laden hydrogels to enhance antibacterial and imaging properties. STAR Protocols (2024)
Mesci P, LaRock C, Jeziorski J, Nakashima H, Chermont N, Ferrasa A, Herai R, Ozaki T, Saleh A, Snethlage C, Sanchez S, Goldberg G, Trujillo C, Nakashima K, Nizet V, Muotri A. Human microglia as a therapeutic target in a neurodevelopmental disease model. Stem Cell Reports (2024)
Ashkarran A, Sharifi S, LaRock C, Mahmoudi M. Improved methodology for evaluating nanomedicine antibacterial properties in biological fluids. ACS Pharmacology and Translational Science (2024)
Do H, Li Z, Tripathi P, Mitra S, Guerra S, Dash A, Weerasekera D, Makthal N, Shams S, Aggarwal S, Singh B, Gu D, Du Y, Olsen R, LaRock C, Zhang W, Kumaraswami M. Engineered probiotic overcomes pathogen defences using signal interference and antibiotic production to treat infection in mice. Nature Microbiology (2024)
Guerra S, LaRock C. Group A Streptococcus interactions with the host across time and space. Current Opinion in Microbiology (2024)
Wilde S, Dash A, Johnson A, Mackey K, Okumura C, LaRock C. Detoxification of reactive oxygen species by the hyaluronic acid capsule of group A Streptococcus. Infection and Immunity (2023)
LaRock D, LaRock C. Assessing Interleukin-1β Activation During Pyroptosis. Methods Mol Biol (2023)
Johnson A, Sands J, Trivedi K, Russell R, LaRock D, LaRock C. Constitutive secretion of pro-IL-18 allows keratinocytes to initiate inflammation during bacterial infection. PLoS Pathogens(2023)
Everett M, Davies D, Leiris S, Sprynski N, Llanos A, Castandet J, Lozano C, LaRock C, LaRock D, Corsica G, Docquier J-D, Pallin D, Cridland A, Blench T, Zalacain M, Lemonnier M. Chemical optimization of selective Pseudomonas aeruginosa LasB elastase inhibitors and their impact on LasB-mediated activation of IL-1β in cellular and animal infection models. ACS Infectious Disease(2023)
Theus A, Ning L, Kabboul G, LaRock C, Bauser-Heaton H, Mahmoudi M, Serpooshan V. 3D bioprinting of nanoparticle-laden hydrogel scaffolds with enhanced antibacterial and imaging properties.iScience (2022)
LaRock D, Johnson A, Wilde S, Sands J, Monteiro M, LaRock C. Group A Streptococcus induces GSDMA-dependent pyroptosis of keratinocytes. Nature (2022)
Johnson A, LaRock C. Antibiotic treatment, mechanisms for failure, and adjunctive therapies for infections by group A Streptococcus. Frontiers in Microbiology (2021)
Johnson A, Sands J, Trivedi K, Russell R, LaRock D, LaRock C. Pro-IL-18 secreted by keratinocytes detects the group A streptococcal protease SpeB. BioRxiv(2021)
Atashgah R, Ghasemi A, Raoufi M, Abdollahifar M, Zanganeh S, Nejadnik H, Abdollahi A, Sharifi S, Lea B, Cuerva M, Akbarzadeh M, Alvarez-Lorenzo C, Ostad S, Theus A, LaRock D, LaRock C, Serpooshan V, Sarrafi R, Lee KB, Vali H, Schönherr H, Gould L, Taboada P, Mahmoudi M. Restoring Endogenous Repair Mechanisms to Heal Chronic Wounds with a Multifunctional Wound Dressing. Molecular Pharmaceutics (2021)
Shokoubimehr M, Theus A, Kamalakar A, Ning L, Cao C, Tomov M, Kaiser J, Goudy S, Willet N, Jang H, LaRock C, Hanna P, Lechtig A, Yousef M, Da Silva Martins J, Nazarian A, Harris M, Mahmoudi M, Serpooshan V. 3D bioprinted bacteriostatic hyperelastic bone scaffold aimed at damage-specific bone regeneration. Polymers (2021)
Wilde S, Olivares K, Hoffman H, Nizet V, Radhakrishna S, LaRock C. Effects of anti-interlekin-6 immunotherapy on opportunistic invasive infection by group A Streptococcus. The Journal of Infectious Diseases (2020)
LaRock D, Russell R, Johnson A, Wilde S, LaRock C. Group A Streptococcus infection of the nasopharynx requires proinflammatory signaling through the Interleukin-1 receptor. Infection and Immunity (2020)
Xia J, Lyons R, Lin M-Y, Khalifa Y, LaRock C. Combination of lidocaine gel and povidone-iodine to decrease acquired infections in procedures performed using topical anesthesia. Journal of Cataract and Refractive Surgery (2020)
Wierzbicki I, Cambeau A, Dehaini D, Holay M, Wei X, Greene T, Ying M, Sands J, Lamsa A, Zuniga E, Pogliano K, Fang R, LaRock C, Zhang L, Gonzalez D. Group A streptococcal S protein utilizes red blood cells as immune camouflage and is a critical determinant for immune evasion. Cell Reports (2019)
LaRock D, Sands J, Ettouati E, Richard M, Bushway P, Adler E, Nizet V, LaRock C. Inflammasome inhibition protects against cardiac glycoside cellular toxicity. The Journal of Biological Chemistry (2019)
Dan J, Havenar-Daughton C, Kendric K, Al-Kolla R, Kaushik K, Rosales S, Anderson E, LaRock C, Seumois G, Layfield D, Cutress R, Ottensmier C, Arlehamn C, Sette A, Nizet V, Bothwell M, Brigger M, Crotty S. Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells. Science Translational Medicine (2019)
Mesci P, Macia A, LaRock CN, Tejwani L, Fernandes IR, Suarez NA, Zanotto PM, Beltrão-Braga PC, Nizet V, Muotri AR. Modeling neuro-immune interactions during Zika virus infection. Human Molecular Genetics (2018)
Valderrama J, Riestra A, Gao N, LaRock C, Ali S, Gupta N, Hoffman H, Ghosh P, Nizet V. Group A streptococcal M protein activates the NLRP3 inflammasome. Nature Microbiology (2017)
Döhrmann S, LaRock C, Anderson E, Cole J, Ryali B, Stewart C, Nonejuie P, Pogliano J, Corriden R, Ghosh P, Nizet V. Group A streptococcal M1 protein provides resistance against the antimicrobial activity of histones. Scientific Reports (2017)
LaRock C, Todd J, LaRock D, Olson J, O’Donoghue A, Robertson A, Cooper M, Hoffman H, Nizet V. IL-1β is an innate immune sensor of microbial proteolysis. Science Immunology (2017)
LaRock C & Cookson B. Burning down the house: cell actions during pyroptosis. PLoS Pathogens (2013)
LaRock C, Yu J, Horswill A, Parsek M, Minion F. Transcriptome analysis of acyl-homoserine lactone based quorum sensing regulation in Yersinia pestis. PLoS One (2013)
LaRock C & Cookson B. The Yersinia virulence effector YopM binds caspase-1 to arrest inflammasome assembly and processing. Cell Host & Microbe (2012)
Livny J, LaRock C, Friedman D. Identification and isolation of lysogens with induced prophage. Methods in Molecular Biology (2009)
Tchesnokova V, Aprikian P, Yakovenko O, LaRock C, Kidd B, Vogel V, Thomas W, Sokurenko E. Integrin-like allosteric properties of the catch bond-forming FimH adhesin of Escherichia coli. The Journal of Biological Chemistry (2008)
Held K, LaRock C, D'Argenio D, Berg C, Collins C. A metalloprotease secreted by the insect pathogen Photorhabdus luminescens induces melanization. Applied & Environmental Microbiology (2007)
